The overall meaning of Global Dan's song "Handz Up" is about his lifestyle and success, with a focus on money, fame, and attracting women. The lyrics describe his desire to be with attractive women and his ability to provide for them financially. He also addresses the jealousy and hate he receives from others, particularly from men who are not as financially successful as him. The song emphasizes his confidence and self-assuredness in his position. Ultimately, the song is a boastful anthem celebrating his wealth and luxurious lifestyle.