The song "On The Run" by Gucci Mane discusses the rapper's involvement in illegal activities, specifically drug trafficking and violence. The lyrics portray Gucci Mane as someone who is constantly on the run from law enforcement and rival gangs, highlighting the dangerous lifestyle he leads. In the song, Gucci Mane references having a .44 caliber gun and urges his enemies to run away to avoid getting shot. He also mentions his connections to drug trade, discussing kilos of cocaine and his association with "black amigo" (a term used to describe drug dealers). Gucci Mane boasts about his wealth and success in the illegal underworld, mentioning his jewelry and expensive lifestyle. The lyrics also touch on Gucci Mane's run-ins with the law, including his mother's house being raided and his status as a "most wanted" criminal. Despite his criminal activities, Gucci Mane states that he is a "real dope boy" who hustles for money. The overall meaning and story of the song depict Gucci Mane as a fearless and dangerous individual who lives a high-risk lifestyle. It conveys the challenges and risks involved in his illegal activities, as well as his desire to maintain his reputation and assert dominance in the streets.