The lyrics of Highway 101's song Setting Me Up express a sense of frustration and betrayal in a relationship. The singer is being praised and told they're great, but they sense that their partner is not genuine in their affection. The partner is manipulating and controlling them, trying to bring them down and make them look foolish. However, the singer has had enough and decides to leave before getting hurt. They don't care about their partner's reactions and want nothing to do with them anymore. The song is a warning to anyone who might be in a similar situation, telling them to give up and stop playing games.