The song "Ready When It Comes" by Jamie O'Neal is about two individuals facing difficult situations in their lives and relying on their faith and perseverance to get through them. The first verse describes a woman who wakes up feeling trapped in her mundane job and the negativity surrounding her. However, she holds onto her one dream and focuses on brighter days to come. The second verse tells the story of a man who is dealing with a serious illness and the overwhelming emotions that come with it. He turns to his loved ones for support and resolves to fight through the difficult times. The chorus emphasizes the importance of having a strong spirit and faith when facing adversity. It speaks to the idea that no matter how tough things get, there is always hope for a better tomorrow. The bridge highlights the power of love and the strength it can provide during challenging times. The song's overall message is one of resilience and positivity, encouraging listeners to remain steadfast in their faith and to be ready for whatever comes their way.