The first part of the song describes the sailors who sailed on ships on Earth in the past. Then the lyrics shift to the California Gold Rush of 1849, when people were traveling from all over to seek their fortune in California. The chorus is about setting sail and leaving for California. The song then takes a futuristic turn, imagining spaceships traveling through the stars and falling in love at the speed of light. The lyrics mention Andromeda, a galaxy 2.5 million light-years away from Earth. The final verse returns to the theme of sailing, but this time it's about the comradery of a group of people who have been through tough times together. The chorus repeats, but with the updated idea of leaving for the stars instead of California. Overall, "Santy Anno" is a song about adventure, exploration, and friendship, with a nod to the past and a futuristic twist.