The song "Mrs. Mistake" by Jesse McCartney is about a man who reflects on his past relationship and realizes that he took his partner for granted. He used to be wealthy and didn't pay attention to the love he had, ultimately causing him to lose his partner and leaving him with a broken heart. The lyrics depict how he used to live a lavish lifestyle, going to clubs, spending money, and being involved with multiple girls, but his true love was waiting for him at home. However, he now regrets his actions and acknowledges that he made a mistake by not fully appreciating her. The song emphasizes that she was the one who got away and the man now compares every other person he meets to her, realizing that he should have settled down with her and built a life together. He accepts the consequences of his actions and understands that he needs to move on, but he still longs for the relationship he had with her. Overall, the song speaks about regret and the realization of losing a love that was taken for granted.