The song "Off With That" by Marie Angelique and Playboi Carti is about overcoming depression and negative emotions by getting off drugs and avoiding toxic situations. The lyrics describe the feeling of being high and detached from reality, but also the realization that it's not a sustainable or healthy way to cope with emotions. The chorus emphasizes the need to get rid of depression and sadness, while the verses highlight the party lifestyle and escapism through drugs. The song also touches on the idea of not wanting to be nice to people who are only interested in superficial things, and the desire to be off that mindset. Overall, the song encourages finding healthier ways to deal with emotions and avoiding negative influences.