The song "Shele" by Shado Vybz talks about the experience of smoking marijuana with friends and the unpredictability of life. The lyrics describe how in the past, the singer and their friends used to smoke different strains of marijuana together, but now they are living a life where nobody knows what the future holds. The chorus repeats the word "amnesia," suggesting that smoking marijuana may lead to forgetting about the uncertainties of life or simply having a good time. Overall, the song captures the carefree attitude of enjoying the present moment while acknowledging the unknown future.