The lyrics of "Iguana" by SiyahXO! talk about the struggles of life and the determination to keep pushing forward. The song talks about the need for money and financial stability, as well as the desire to blend in and adapt to one's surroundings like a camouflage-wearing iguana. The mention of Savannah, Georgia adds a Southern twist to the story, highlighting the gritty realities of trying to make ends meet and survive in a tough environment. The overall message is about resilience and perseverance in the face of adversity.