The song "300 Bars & Runnin'" by The Game is a famous diss track in which he takes aim at various artists and figures in the hip-hop industry, primarily targeting 50 Cent and G-Unit. The song was released in 2005 as a response to 50 Cent's diss track "Piggy Bank." In the song's intro, The Game reminisces about his childhood, particularly about going to Sam Goody's to buy a 50 Cent CD. However, he expresses disappointment with the music, calling it wack. He then asserts that he doesn't mess with 50 Cent and starts dissing him. The intro also includes references to popular TV characters like Spongebob and Blues Clues to mock 50 Cent's crew, including Tony Yayo and Lloyd Banks. The Game sarcastically calls them his friends and then says "Psyche," indicating he doesn't actually consider them as friends. Moving into the main verse, The Game talks about going to a bodega in Harlem to get a bootleg CD of Lloyd Banks and Young Buck. He puts it in his boombox, expecting to hear great music but feels disappointed when it sounds outdated and compares it to Vanessa Williams' music from 1988. He also mentions rumors about Olivia, another artist affiliated with G-Unit, being transgender. The song's title, "300 Bars & Runnin'," refers to the length of the track and The Game's intention to deliver lengthy, continuous disses towards his targets. He essentially uses the song to express his feelings of frustration, discontent, and rivalry towards 50 Cent and G-Unit. Throughout the song, The Game presents himself as an underdog, stating that he will stand up against G-Unit and not back down. He proclaims loyalty to his crew, Black Wallstreet, and states GGG-UNOT, meaning G-Unit Get Gunned Up but You're Not on Top. The song's purpose was to directly respond to 50 Cent's diss track and establish The Game's presence and lyrical skills in the rap game. It became a standout moment in hip-hop history and further fueled the ongoing feud between The Game and G-Unit.