The song "Brother & Sister" by Uncle Murda tells the story of a brother and sister living in a difficult and challenging environment. The lyrics describe the struggles they face and the choices they make in order to survive and provide for their family. The brother is portrayed as a street hustler who takes on the responsibility of being the man of the house. He hustles and grinds to put food on the table and pay the bills. He prioritizes taking care of his younger sister, ensuring that she attends school regularly and excels academically. As time goes on, the sister grows up and enters college, still maintaining her innocence as she chooses to remain a virgin. However, a conflict arises when she is involved in an altercation with a group of boys who disrespect their mother. The brother takes matters into his own hands and seeks revenge but fails to eliminate the intended target. Eventually, the brother is caught and imprisoned, leaving the sister to face the hardships on her own. She struggles financially and faces pressure from the same boy who had disrespected their mother. In a turn of events, she ends up sleeping with him and becomes pregnant. The brother, unaware of these events, finds out about his sister's actions while in prison, causing him to become furious and lose hope. The song ends with a cliffhanger, with the narrator promising to reveal the rest of the story when the brother is released from prison. Overall, "Brother & Sister" portrays the harsh realities faced by individuals growing up in difficult circumstances and highlights the impact of choices on their lives and relationships.