"Biol-101" is a song by Jay Wheeler and Jorge Milliano. The song revolves around a relationship between two individuals, particularly a girl the artist is attracted to. The lyrics describe the girl as being different from others, and her parents are unaware of her hidden desires for mischief. The song mentions how the girl escapes with the artist to places without any witnesses, suggesting a sense of thrill and secrecy in their relationship. The lyrics imply that the girl transforms when they are intimate, with both experiencing a sense of euphoria where they are disconnected from gravity. The artist expresses a desire for their encounters to never end. The chorus emphasizes the unique feeling the artist experiences when "bellaquear" (a Puerto Rican slang term meaning to behave in a seductive or flirtatious manner) with the girl. It states that the feeling is so intense that one night is never enough. The repetition of "qué rico se siente" (how good it feels) emphasizes the pleasurable experience they share. Overall, the song depicts a passionate and exciting relationship between two individuals who take pleasure in the thrill and intensity of their time spent together.