The lyrics of "Headache" by JayKae show the rapper reflecting on his life and experiences. He pays tribute to his friends who have passed away and vows to live his life differently by being more responsible. JayKae also talks about his desire to succeed in the music industry and leave his current environment behind. He acknowledges that some people may not understand his lifestyle but he continues to pursue his dreams. The song also features themes of loyalty, betrayal, and perseverance. Overall, "Headache" is a message to his fans and critics that he is determined to succeed despite any obstacles he may face.