The song "Can't Ignore" by John Gabbana is about trying to run away from something or someone, but always being followed or unable to ignore the situation. The lyrics suggest that making sacrifices is necessary in life and that struggles are inevitable, particularly when living on your own and feeling alone. The song touches on the theme of having to hustle and do whatever it takes to survive, even if it means resorting to illegal activities such as robbery. The artist shares his personal experience of feeling like his smiles are forced and trying to delete memories but being unable to do so. The overall message is that it's important to acknowledge and confront the challenges in life, even if they are difficult to face.