"Give It Up" by John Hiatt tells the story of someone who is trapped in a cycle of addiction and self-destruction. The lyrics describe a person who takes what they want without considering the consequences or the needs of others. They continue on this destructive path, running through life with reckless abandon and refusing to believe in anything beyond their own desires. The song emphasizes the thin line between satisfaction and disappointment, as the character's shallow desires constantly trip them up. Despite their pursuit of instant gratification, they find themselves unsatisfied and empty. The lyrics mention Sally, possibly a former lover or friend, who may still care for the character despite their struggles. Sally recognizes that the character needs to make their own decisions and change their ways, and may be willing to offer help for the last time. As the song progresses, the character's situation worsens. The nights become longer, and they dread each new day. The pain they feel, both physical and emotional, illustrates their loss of control and the damage they have inflicted upon themselves. It symbolizes a beast within them, representing their addiction, taking control of their life and tearing away their soul. The chorus of the song urges the character to give up their destructive habits and take responsibility for their actions. It emphasizes the need to find the willpower to change and seek support. The repetition of the phrase "give it up" reflects the urgency and importance of making a change before it's too late. Overall, "Give It Up" is a powerful and desperate plea for redemption and escape from a life consumed by addiction. It highlights the destructive nature of self-indulgence and the potential consequences that can arise from disregarding the needs of others.