The song Perfect Melody by Jonas Blue & Julian Perretta is about regretting the mistakes made in a past relationship. The singer struggles to understand why they did wrong and wishes they could go back to the perfect moments they shared with their partner. The lyrics repeatedly mention a perfect melody, symbolizing the happy times they had together. The singer expresses their deep emotions and how they feel incomplete without their partner. Overall, the song conveys a bittersweet feeling of nostalgia for a lost love.