The song "Biggest Mistake" by Joseph Arthur explores themes of regret and missed opportunities in a romantic relationship. The lyrics reflect on the mistakes made by both parties involved, resulting in a sense of loneliness and longing. The first verse describes how the person who left their partner realizes that it was a big mistake. They acknowledge that together, they made the world a less lonely place and that their partner was their best friend. However, they failed to fully open up and let their partner in, hence the line "Even though you hardly let me in, I could tell how you were running." In the chorus, the speaker expresses their concern about wasting their partner's time and not fully understanding their pain. They are unsure of their partner's intentions and don't want to lead them on, but at the same time, they don't want to waste their own time either. In the bridge, the speaker is reaching out, indicating their willingness to reconcile and mend the relationship. They understand that their partner probably saw how they themselves were also running away from their emotions. Overall, the song portrays the complexities of a relationship where both individuals have made mistakes and are now reflecting on what could have been. It highlights the importance of communication, vulnerability, and the potential for reconciliation.