"Give Her The Keys" by E-40 is a song about appreciating and recognizing the loyalty and support of a partner. The song talks about the journey from humble beginnings to success and how the partner has been there through thick and thin. E-40 starts by mentioning how his partner has been with him since his early days, always having his back. He acknowledges that she hid his drugs when he was involved in illegal activities, showing her commitment to him. He cherishes her and has a special place for her in his heart. The song highlights the chemistry and similarities between the couple, emphasizing how they make a good team. They understand each other and have a deep connection. E-40 mentions their shared upbringing and experiences, solidifying their bond. E-40 also appreciates the smaller things that his partner does for him. He acknowledges that even the little gestures count and mean a lot to him. He believes that nothing can come between them and separates them. The partner is described as his backbone, rib, and chick, emphasizing her importance in his life. Overall, "Give Her The Keys" is a tribute to a loyal and supportive partner. It celebrates the strength of their relationship and the deep connection they share.