E-40's song "My Hoodlumz & My Thugz" celebrates the loyalty and camaraderie of individuals living in the ghetto and involved in street life. The lyrics describe the pledge of allegiance to various elements of their lifestyle, including the ghetto, the game (street life), money, cars, women, and fame. The song's chorus acknowledges and embraces the hoodlums and thugs who wear their "mugs on" in the ghetto and hood. It portrays activities such as cooking drugs, handling packages, and grinding out of taxicabs as part of their daily routine. The repeated phrase "throw it up" is a call to represent their neighborhood, brothers, or gang affiliation. The verse by WC emphasizes the gangster lifestyle, with rhymes about violence, survival, and amassing wealth. He references his dedication to the trigger and his loyalty to his hoodlum and thug brothers. E-40's verse follows a similar theme, highlighting his knowledge and involvement in the drug trade. He boasts about his resilience under pressure and brags about his desired possessions, such as expensive alcohol and guns. He also mentions his connections in Brooklyn and how he outshines his opponents. Mack 10's verse dives into his life as a gang member in Inglewood. He describes his involvement in the dope game, his financial success, and having control over a woman who is willing to kill for him. Overall, the song portrays a sense of pride in the street life, emphasizing loyalty to one's neighborhood and the pursuit of wealth and power. It reflects the realities and mindset of individuals living in the ghetto, celebrating their resilience and determination to succeed against all odds.