"One Night Stand" by E-40 is a song about a man who approaches a woman in a club and proposes the idea of having a one-night stand. The lyrics depict his intentions of not wanting a committed relationship, but rather to engage in a casual sexual encounter. The song begins with DJ Kayslay hyping up the crowd and introducing E-40, emphasizing that this is going to be a memorable and energetic performance. E-40 then starts rapping, showcasing his signature style of rhyming and wordplay. In the chorus, E-40 expresses his attraction to a woman and asks if he can buy her a drink. He suggests the idea of having a one-night stand, highlighting his lack of interest in a long-term relationship. However, he also mentions his willingness to get to know each other over drinks. Throughout the song, E-40 flexes his wealth and success, mentioning his money, cars, and expensive possessions. He brags about his status in the rap game and his knack for creating unique slang and catchphrases. The chorus is repeated multiple times, reinforcing the song's main theme of a casual encounter rather than an emotional connection. E-40 ends the song by emphasizing the importance of living life to the fullest and celebrating each day. Overall, "One Night Stand" is a song that portrays E-40's confident and carefree attitude towards casual relationships and showcases his distinctive rap style and lyrical abilities.