"Wake They Shit Up" by E-40 is a song about not forgetting about past offenses and getting revenge. The lyrics depict a scenario where someone has been wronged or disrespected, but instead of immediately retaliating, they choose to let time pass and let things settle down. However, when the perpetrators think that the situation has been forgotten and continue with their lives, the person confronts them and "wakes their shit up," essentially seeking revenge and making them pay for their actions. The song also touches on various social issues, such as the corrupt justice system and the struggles faced by marginalized communities. E-40 reflects on how the system is designed against people of color and highlights the efforts of youth activists and non-profit organizations to bring about change. Additionally, the lyrics emphasize the importance of staying vigilant and prepared for potential dangers, as even within someone's own community, they can be set up or betrayed. Overall, "Wake They Shit Up" serves as a reminder to not forget past wrongdoings and to stand up for oneself when the time is right, while also shedding light on societal challenges and the need for unity and empowerment.